I've got a thing for pistols in any game that lets me carry a gun, so I completely ignore explosives, energy weapons and any other skill that boosts a weapon other than guns.
I don't grasp the concept of playing this and F03 in melee so I completely ignore everything relating to unarmed or hand-to-hand combat. My build is similar to yours but rather than make strength high I went for perception.
Said: ' SPECIAL put most into agility, strength and intelligence Skills sneak, melee/unarmed (which one is generally better?), guns, science, speech.